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Sickle-cell is an inherited red blood disorder that affects around 15,000 people in the UK, particularly those from African and Asian communities. It’s currently on the increase and particularly dangerous for pregnant women. The Royal College of Obstetricians and Gynaecologists has just issued new guidelines to help manage the disease. But how do you know if you have the condition and what can be done to control it effectively during pregnancy? Jenni Murray speaks to Jo Howard, Consultant Haematologist at Guy's and St Thomas' Hospital, and to a sickle cell patient who has experienced complicated pregnancies.